Öz
Sialorrhea is defined as excessive saliva secretion and flowing from the corner of the mouth. Correct identification of the underlying cause is important for the treatment of this condition, which can lead to many physical and psychosocial complications and significantly reduces the person's quality of life. Many factors are involved in its etiology, and it may also appear as a side effect due to drug use in the clinic. Although clozapine is the drug most associated with sialorrhea among the drugs used in psychiatry, there are publications indicating that sialorrhea may also occur due to many other psychotropic drugs. Therefore, drug side effects should also be considered in the etiology of sialorrhea in people using psychotropic drugs. In this article, it is aimed to contribute to the existing literature by discussing sialorrhea due to risperidone use in a 59-year-old female patient followed up with a diagnosis of non-organic psychosis, in the light of literature findings.
Anahtar Kelimeler
Kaynakça
- Orhan Özturan, Ömer Faruk Çalım. Siyaloreli hastaya yaklaşım ve tedavi yönetimi. no. 39–47, Kulak Burun Boğaz Uygulamaları Dergisi, 2018.
- Heikel T, Patel S, Ziai K, Shah SJ, Lighthall JG. Botulinum toxin a in the management of pediatric sialorrhea: a systematic review. Ann Otol Rhinol Laryngol. 2023 Feb;132(2):200-206. doi: 10.1177/00034894221078365. Epub 2022 Feb 18. PMID: 35176902; PMCID: PMC9834812.
- Hockstein NG, Samadi DS, Gendron K, Handler SD. Sialorrhea: a management challenge. Am Fam Physician. 2004 Jun 1;69(11):2628-34. PMID: 15202698.
- Liang CS, Liao WC, Yang FW, Ho PS. Risperidone-induced sialorrhea: dose-related? Pharmacopsychiatry. 2010 Nov;43(7):282-3. doi: 10.1055/s-0030-1265197. Epub 2010 Oct 6. PMID: 20927701.
- Torrico T, Kahlon A. Pathophysiology and management of risperidone-induced sialorrhea: case report. Front Psychiatry. 2023 Jul 13;14:1185750. doi: 10.3389/fpsyt.2023.1185750. PMID: 37520231; PMCID: PMC10372792.
- Usta MG, Tufan AE, Cüceloğlu EA. Diphenhydramine use in the treatment of risperidone-induced sialorrhea. J Child Adolesc Psychopharmacol. 2012 Jun;22(3):254-5. doi: 10.1089/cap.2011.0097. Epub 2012 Apr 26. PMID: 22537186.
- Cuvelier E, Gressier B, Fovet T, Simon N, Décaudin B, Amad A. Prise en charge de l’hypersialorrhée iatrogène : revue de la littérature et recommandations pratiques [treatment options for drug-induced sialorrhea: prescribing guidelines]. Encephale. 2022 Dec;48(6):700-711. French. doi: 10.1016/j.encep.2022.03.013. Epub 2022 Aug 18. PMID: 35989107.
- Halder A, Ravindran NP, Nagda P, Harshe D, Harshe G. Review of psychotropic agents associated with sialorrhoea, except clozapine. Indian J Psychol Med. 2023 Jan;45(1):14-18. doi: 10.1177/02537176211025789. Epub 2021 Aug 9. PMID: 36778614; PMCID: PMC9896114.
- Panagiotidis PT, Fountoulakis KN, Siamouli M, Magiria S, Iacovides A, Kaprinis G. Risperidone-induced sialorrhea responsive to biperiden treatment. Schizophr Res. 2007 Jul;93(1-3):410-1. doi: 10.1016/j.schres.2007.03.006. Epub 2007 Apr 25. PMID: 17462863.
- Prljača E, Bećirović E, Hasanović M, Pajević I, Brigić A. Clozapine-induced hypersalivation treated with sulpiride - is it a solution? Psychiatr Danub. 2021 Spring;33(Suppl 4):1230-1232. PMID: 35354192.
- Mutlu E, Özçelik Eroğlu E, Coşkun FÖ, Koçyiğit D, Canpolat İKN, Avcı H, Ertuğrul A, Anıl Yağcıoğlu AE. A systematic chart review of pharmacological interventions in patients with clozapine-induced hypersalivation. Schizophr Res. 2023 Aug 17:S0920-9964(23)00262-1. doi: 10.1016/j.schres.2023.08.004. Epub ahead of print. PMID: 37597972.
- Burk BG, Donaldson V, Jackson CW, Cates ME, Birur B. Paliperidone-associated sialorrhea: a case report with review of current literature. J Clin Psychopharmacol. 2022 Sep-Oct 01;42(5):480-484. doi: 10.1097/JCP.0000000000001588. Epub 2022 Aug 8. PMID: 35943409.
- Gajwani P, Franco-Bronson K, Tesar GE. Risperidone-induced sialorrhea. Psychosomatics. 2001 May-Jun;42(3):276. doi: 10.1176/appi.psy.42.3.276. PMID: 11351120.
Öz
Siyalore, tükürüğün aşırı salgılanması ve ağız köşesinden akması olarak tanımlanır. Fiziksel ve psikososyal pek çok komplikasyona yol açabilen ve kişinin yaşam kalitesini önemli ölçüde düşüren bu durumun tedavisi için altta yatan nedenin doğru belirlenmesi önemlidir. Etiyolojisinde pek çok faktör rol oynadığı gibi klinikte ilaç kullanımına bağlı yan etki olarak da ortaya çıkabilmektedir. Psikiyatride kullanılan ilaçlar arasında siyalore ile en çok ilişkilendirilen ilaç klozapin olmasına rağmen, diğer birçok psikotrop ilaç nedeniyle de siyalorenin ortaya çıkabileceğini belirten yayınlar bulunmaktadır. Bu nedenle psikotrop ilaç kullanan kişilerde, siyalore etiyolojisinde ilaç yan etkisi de göz önünde bulundurulmalıdır. Bu yazıda, organik olmayan psikoz tanısıyla takip edilen 59 yaşında kadın hastada risperidon kullanımına bağlı siyalorenin literatür bulguları ışığında tartışılarak mevcut literatüre katkı sağlanması amaçlanmaktadır.
Anahtar Kelimeler
Kaynakça
- Orhan Özturan, Ömer Faruk Çalım. Siyaloreli hastaya yaklaşım ve tedavi yönetimi. no. 39–47, Kulak Burun Boğaz Uygulamaları Dergisi, 2018.
- Heikel T, Patel S, Ziai K, Shah SJ, Lighthall JG. Botulinum toxin a in the management of pediatric sialorrhea: a systematic review. Ann Otol Rhinol Laryngol. 2023 Feb;132(2):200-206. doi: 10.1177/00034894221078365. Epub 2022 Feb 18. PMID: 35176902; PMCID: PMC9834812.
- Hockstein NG, Samadi DS, Gendron K, Handler SD. Sialorrhea: a management challenge. Am Fam Physician. 2004 Jun 1;69(11):2628-34. PMID: 15202698.
- Liang CS, Liao WC, Yang FW, Ho PS. Risperidone-induced sialorrhea: dose-related? Pharmacopsychiatry. 2010 Nov;43(7):282-3. doi: 10.1055/s-0030-1265197. Epub 2010 Oct 6. PMID: 20927701.
- Torrico T, Kahlon A. Pathophysiology and management of risperidone-induced sialorrhea: case report. Front Psychiatry. 2023 Jul 13;14:1185750. doi: 10.3389/fpsyt.2023.1185750. PMID: 37520231; PMCID: PMC10372792.
- Usta MG, Tufan AE, Cüceloğlu EA. Diphenhydramine use in the treatment of risperidone-induced sialorrhea. J Child Adolesc Psychopharmacol. 2012 Jun;22(3):254-5. doi: 10.1089/cap.2011.0097. Epub 2012 Apr 26. PMID: 22537186.
- Cuvelier E, Gressier B, Fovet T, Simon N, Décaudin B, Amad A. Prise en charge de l’hypersialorrhée iatrogène : revue de la littérature et recommandations pratiques [treatment options for drug-induced sialorrhea: prescribing guidelines]. Encephale. 2022 Dec;48(6):700-711. French. doi: 10.1016/j.encep.2022.03.013. Epub 2022 Aug 18. PMID: 35989107.
- Halder A, Ravindran NP, Nagda P, Harshe D, Harshe G. Review of psychotropic agents associated with sialorrhoea, except clozapine. Indian J Psychol Med. 2023 Jan;45(1):14-18. doi: 10.1177/02537176211025789. Epub 2021 Aug 9. PMID: 36778614; PMCID: PMC9896114.
- Panagiotidis PT, Fountoulakis KN, Siamouli M, Magiria S, Iacovides A, Kaprinis G. Risperidone-induced sialorrhea responsive to biperiden treatment. Schizophr Res. 2007 Jul;93(1-3):410-1. doi: 10.1016/j.schres.2007.03.006. Epub 2007 Apr 25. PMID: 17462863.
- Prljača E, Bećirović E, Hasanović M, Pajević I, Brigić A. Clozapine-induced hypersalivation treated with sulpiride - is it a solution? Psychiatr Danub. 2021 Spring;33(Suppl 4):1230-1232. PMID: 35354192.
- Mutlu E, Özçelik Eroğlu E, Coşkun FÖ, Koçyiğit D, Canpolat İKN, Avcı H, Ertuğrul A, Anıl Yağcıoğlu AE. A systematic chart review of pharmacological interventions in patients with clozapine-induced hypersalivation. Schizophr Res. 2023 Aug 17:S0920-9964(23)00262-1. doi: 10.1016/j.schres.2023.08.004. Epub ahead of print. PMID: 37597972.
- Burk BG, Donaldson V, Jackson CW, Cates ME, Birur B. Paliperidone-associated sialorrhea: a case report with review of current literature. J Clin Psychopharmacol. 2022 Sep-Oct 01;42(5):480-484. doi: 10.1097/JCP.0000000000001588. Epub 2022 Aug 8. PMID: 35943409.
- Gajwani P, Franco-Bronson K, Tesar GE. Risperidone-induced sialorrhea. Psychosomatics. 2001 May-Jun;42(3):276. doi: 10.1176/appi.psy.42.3.276. PMID: 11351120.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri (Diğer) |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Erken Görünüm Tarihi | 28 Nisan 2024 |
| Yayımlanma Tarihi | 30 Nisan 2024 |
| Gönderilme Tarihi | 3 Ocak 2024 |
| Kabul Tarihi | 26 Mart 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 5 Sayı: 1 |
