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Prophylactic and Therapeutic Probiotic Use in Children

Year 2024, Volume: 8 Issue: 1, 32 - 43, 30.04.2024

Ece Tüsüz Önata Öner Özdemir

https://doi.org/10.34084/bshr.1465778

Abstract

Probiotics are live microorganisms that provide health benefits when administered in adequate amounts. By adhering to the intestinal epithelium and mucus, probiotics compete with pathogens, reducing pathogen invasion, and produce antimicrobial substances such as bacteriocins, hydrogen peroxide, and organic acids, thereby exerting antimicrobial effects. Due to these effects, the use of probiotics has been a subject of research for the prevention and treatment of gastrointestinal diseases for many years. The systemic effects of probiotics, such as inducing the production of regulatory T cells and redirecting the response to allergens towards the Th1 direction, have provided hope for their use in allergic diseases. In recent years, research has been conducted on many diseases in which probiotics are used for prophylactic or therapeutic purposes. From these studies, important evidence has been obtained showing that the effectiveness of probiotics is specific to the strain and the disease. The purpose of this article is to review the disease-specific use of probiotics in the light of current literature.

Keywords

probiotics children therapy prophylaxis

Ethical Statement

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Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı

Year 2024, Volume: 8 Issue: 1, 32 - 43, 30.04.2024

Ece Tüsüz Önata Öner Özdemir

https://doi.org/10.34084/bshr.1465778

Abstract

Probiyotikler uygun miktarda uygulandıklarında kişiye sağlık açısından fayda sağlayan canlı mikroorganizmalardır. Probiyotikler bağırsak epiteli ve mukusuna yapışma yetenekleri sayesinde patojenlerle yarışarak patojen istilasını azaltırlar, bakteriyosin, hidrojen peroksit ve organik asitler gibi antimikrobiyal ürünler üretip antimikrobiyal etki sağlarlar. Bu etkileri sayesinde probiyotiklerin özellikle gastrointestinal sistem hastalıklarının önlenmesi ve tedavisinde kullanımı uzun yıllardır araştırma konusu olmuştur. Probiyotiklerin regülatör T hücre üretiminin indüklenmesi, alerjenlere cevabın Th1 yönüne saptırılması gibi sistemik etkileri olması alerjik hastalıklarda kullanımı için umut olmuştur. Son yıllarda probiyotiklerin profilaktik veya tedavi amaçlı kullanıldığı pek çok hastalıkla ilgili araştırmalar yapılmaktadır. Bu çalışmalardan probiyotiklerin etkinliğinin suş ve hastalık açısından özel olduğunu gösteren önemli kanıtlar elde edilmiştir. Bu yazının amacı probiyotiklerin hastalık tipine bağlı kullanımını güncel bilgiler ışığında gözden geçirmektir.

Keywords

probiyotik çocuk tedavi profilaksi

Project Number

Yok

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There are 109 citations in total.

Details

Primary Language Turkish
Subjects Clinical Nutrition
Journal Section Review
Authors

Ece Tüsüz Önata 0000-0002-0180-9093

Öner Özdemir 0000-0002-5338-9561

Project Number Yok
Early Pub Date May 19, 2024
Publication Date April 30, 2024
Submission Date April 5, 2024
Acceptance Date April 23, 2024
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

AMA Tüsüz Önata E, Özdemir Ö. Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı. J Biotechnol and Strategic Health Res. April 2024;8(1):32-43. doi:10.34084/bshr.1465778

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